Performance evaluation of cooperation strategies for m-health services and applications

Health telematics are becoming a major improvement for patients’ lives, especially for disabled, elderly, and chronically ill people. Information and communication technologies have rapidly grown along with the mobile Internet concept of anywhere and anytime connection. In this context, Mobile Health (m-Health) proposes healthcare services delivering, overcoming geographical, temporal and even organizational barriers. Pervasive and m-Health services aim to respond several emerging problems in health services, including the increasing number of chronic diseases related to lifestyle, high costs in existing national health services, the need to empower patients and families to self-care and manage their own healthcare, and the need to provide direct access to health services, regardless the time and place. Mobile Health (m- Health) systems include the use of mobile devices and applications that interact with patients and caretakers. However, mobile devices have several constraints (such as, processor, energy, and storage resource limitations), affecting the quality of service and user experience. Architectures based on mobile devices and wireless communications presents several challenged issues and constraints, such as, battery and storage capacity, broadcast constraints, interferences, disconnections, noises, limited bandwidths, and network delays. In this sense, cooperation-based approaches are presented as a solution to solve such limitations, focusing on increasing network connectivity, communication rates, and reliability. Cooperation is an important research topic that has been growing in recent years. With the advent of wireless networks, several recent studies present cooperation mechanisms and algorithms as a solution to improve wireless networks performance. In the absence of a stable network infrastructure, mobile nodes cooperate with each other performing all networking functionalities. For example, it can support intermediate nodes forwarding packets between two distant nodes. This Thesis proposes a novel cooperation strategy for m-Health services and applications. This reputation-based scheme uses a Web-service to handle all the nodes reputation and networking permissions. Its main goal is to provide Internet services to mobile devices without network connectivity through cooperation with neighbor devices. Therefore resolving the above mentioned network problems and resulting in a major improvement for m-Health network architectures performances. A performance evaluation of this proposal through a real network scenario demonstrating and validating this cooperative scheme using a real m-Health application is presented. A cryptography solution for m-Health applications under cooperative environments, called DE4MHA, is also proposed and evaluated using the same real network scenario and the same m-Health application. Finally, this work proposes, a generalized cooperative application framework, called MobiCoop, that extends the incentive-based cooperative scheme for m-Health applications for all mobile applications. Its performance evaluation is also presented through a real network scenario demonstrating and validating MobiCoop using different mobile applications

Content storage and retrieval mechanisms for vehicular delay-tolerant networks

Vehicular delay-tolerant networks (VDTNs) were proposed as a novel disruptive network concept based on the delay tolerant networking (DTN) paradigm. VDTN architecture uses vehicles to relay messages, enabling network connectivity in challenging scenarios. Due to intermittent connectivity, network nodes carry messages in their buffers, relaying them only when a proper contact opportunity occurs. Thus, the storage capacity and message retrieving of intermediate nodes directly affects the network performance. Therefore, efficient and robust caching and forwarding mechanisms are needed. This dissertation proposes a content storage and retrieval (CSR) solution for VDTN networks. This solution consists on storage and retrieval control labels, attached to every data bundle of aggregated network traffic. These labels define cacheable contents, and apply cachecontrol and forwarding restrictions on data bundles. The presented mechanisms gathered several contributions from cache based technologies such as Web cache schemes, ad-hoc and DTN networks. This solution is fully automated, providing a fast, safe, and reliable data transfer and storage management, while improves the applicability and performance of VDTN networks significantly. This work presents the performance evaluation and validation of CSR mechanisms through a VDTN testbed. Furthermore it presents several network performance evaluations and results using the well-known DTN routing protocols, Epidemic and Spray and Wait (including its binary variant). The comparison of the network behavior and performance on both protocols, with and without CSR mechanisms, proves that CSR mechanisms improve significantly the overall network performance

Design science approach

Funding Information: This project (PrimaryCare@COVID-19: Digital Platform for Supporting Chronic Patients and COVID-19 consultations and Monitoring in Primary Care) was funded by the Funda??o para a Ci?ncia e Tecnologia (Ministry of Science of Technology, Portugal) under the Research4COVID-19 program. Funding Information: This project (PrimaryCare@COVID-19: Digital Platform for Supporting Chronic Patients and COVID-19 consultations and Monitoring in Primary Care) was funded by the Fundação para a Ciência e Tecnologia (Ministry of Science of Technology, Portugal) under the Research4COVID-19 program. Publisher Copyright: © 2021 Luís Velez Lapão, Mariana Peyroteo, Melanie Maia, Jorge Seixas, João Gregório, Miguel Mira da Silva, Bruno Heleno, Jorge César Correia.Background: The COVID-19 pandemic is straining health systems and disrupting the delivery of health care services, in particular, for older adults and people with chronic conditions, who are particularly vulnerable to COVID-19 infection. Objective: The aim of this project was to support primary health care provision with a digital health platform that will allow primary care physicians and nurses to remotely manage the care of patients with chronic diseases or COVID-19 infections. Methods: For the rapid design and implementation of a digital platform to support primary health care services, we followed the Design Science implementation framework: (1) problem identification and motivation, (2) definition of the objectives aligned with goal-oriented care, (3) artefact design and development based on Scrum, (4) solution demonstration, (5) evaluation, and (6) communication. Results: The digital platform was developed for the specific objectives of the project and successfully piloted in 3 primary health care centers in the Lisbon Health Region. Health professionals (n=53) were able to remotely manage their first patients safely and thoroughly, with high degrees of satisfaction. Conclusions: Although still in the first steps of implementation, its positive uptake, by both health care providers and patients, is a promising result. There were several limitations including the low number of participating health care units. Further research is planned to deploy the platform to many more primary health care centers and evaluate the impact on patient's health related outcomes.publishersversionpublishe

a digital humanities platform to explore the Portuguese cultural heritage

LISBOA-01-0145-FEDER-022139The ROSSIO Infrastructure is developing a free and open-access platform for aggregating, organising, and connecting the digital resources in the Social Sciences, Arts and Humanities provided by Portuguese higher education and cultural institutions. This paper presents an overview of the ROSSIO Infrastructure, its main objectives, the institutions involved, and the services offered by the infrastructure’s aims through its platform—namely, a discovery portal, digital exhibitions, collections, and a virtual research environment. These services rely on a metadata-aggregation solution for bringing the digital objects’ metadata from the providing institutions into ROSSIO. The aggregated datasets are converted into linked data and undergo an enrichment process based on controlled vocabularies, which are developed and published by ROSSIO. The paper will describe this process, the applications involved, and how they interoperate. We will further reflect on how these services may enhance the dissemination of science, considering the FAIR principles.publishersversionpublishe

a digital research tool for Social Sciences, Arts and Humanities

LISBOA-01-0145-FEDER-022139ROSSIO Infrastructure is building an open-access and free platform that aims to aggregate, organise and connect digital resources related to Social Sciences, Arts and Humanities located in Portuguese educational and cultural institutions. This paper aims to present ROSSIO infrastructure, the institutions involved, its main goals and the services it will provide, such as a discovery portal, exhibitions, collections and a virtual research environment. Underlying these services is a metadata aggregation approach that brings into ROSSIO the metadata on digital objects from the providing institutions. The aggregated dataset is transformed into linked data and enriched with entities from controlled vocabularies, which are defined by ROSSIO. We will detail this process, including the applications employed and how they interoperate. Finally, we will conclusively reflect on the potentialities of these services for public dissemination of science, taking into account the FAIR principles.publishersversionpublishe

Cyber-Cosmos: A New Citizen Science Concept in A Dark Sky Destination

Astrotourism and related citizen science activities are becoming a major trend of a sustainable, high-quality tourism segment, core elements to the protection of Dark skies in many countries. In the Summer of 2020, in the middle of COVID pandemics, we started an initiative to train young students - Cyber-Cosmos - using an Unistellar eVscope, a smart, compact and user-friendly digital telescope that offers unprecedented opportunities for deep-sky observation and citizen science campaigns. Sponsored by the Ci\^encia Viva Summer program, this was probably the first continuous application of this equipment in a pedagogical and citizen-science context, and in a pandemic context. Pampilhosa da Serra, home to a certified Dark Sky destination (Aldeias do Xisto) in central Portugal, was the chosen location for this project, where we expect astrotourism and citizen science to flourish and contribute to space sciences education.Comment: Manuscript presented at the International Astronautical Congress, IAC 2021, Dubai, United Arab Emirates, 25 - 29 October 2021. Copyright by IA

Manipulating the number of players and targets in team sports : small-sided games during physical education classes

This study aimed to examine the effects of players and targets number variation on technical, tactical and physiological indicators in basketball, handball and indoor football. Nine 8th grade students (age 13.3 ± 0.7 years, stature 166.8 ± 3.8 cm, body mass 55.3 ± 4.2 kg) participated in four small-sided games (SSG) for each sport. Despite the differences between the sports, similar average values for technical and tactical indicators were found in both basketball and indoor football SSG. An increase in the number of players affected the duration of unsuccessful offensive phases, the number of passes per offensive phase, successful passes per offensive phase and decreased ball possession per player. Whilst all SSG in this study imposed high physiological demands, 3-a-side games played with one target elicited the greatest responses. In conclusion, the 3-a-side SSG promoted similar technical-tactical indicators and higher physiological demands than 4-a-side SSG.Este estudio tuvo como objetivo examinar los efectos del número de jugadores y metas en la variación de los indicadores técnicos, tácticos y fisiológicos en baloncesto, balonmano y fútbol sala. Nueve estudiantes del octavo grado (edad 13.3 ± 0.7 años, estatura 166.8 ± 3.8 cm, masa corporal 55.3 ± 4.2 kg) participarón en cuatro juegos reducidos (SSG) para cada deporte. A pesar de las diferencias entre los deportes, se encontrarón valores medios similares en los indicadores técnicos y tácticos tanto en los juegos reducidos del baloncesto como en los de fútbol sala. El aumento de los jugadores ha provocado el aumento de la duración de la fase ofensiva sin éxito, número de pases por fase ofensiva, pases acertados por fase ofensiva y ha provocado una disminución de la posesión del balón por jugador. Mientras la totalidad de juegos reducidos utilizados en este estudio han impuesto un elevada demanda fisiológica, los juegos reducidos de 3x3 jugados con una meta provocaron las mayores respuestas. En conclusión, los juegos reducidos de 3x3 ha inducido valores similares en los indicadores técnico-tácticos, pero demandas fisiológicas más altas que los juegos reducidos de 4x4.Este estudo teve como objectivo analisar os efeitos do número de jogadores e dos objectivos na variação dos indicadores técnicos, tácticos e fisiológicos no basquetebol, andebol e futsal. Nove estudantes do oitavo ano (idade 13.3 ± 0.7 anos, estatura 166.8 ± 3.8 cm, massa corporal 55.3 ± 4.2 kg) participaram em quatro jogos reduzidos (SSG) para cada modalidade. Apesar das diferenças entre os desportos, foram verificados valores médios similares nos indicadores técnicos e tácticos nos jogos reduzidos de basquetebol e futsal. O aumento dos jogadores provocou o aumento da duração da fase ofensiva sem êxito, número de passes por fase ofensiva, passes certos por fase ofensiva e provocou uma diminuição da posse de bola por jogador. Enquanto a totalidade de jogos reduzidos utilizados neste estudo implicou uma elevada exigência fisiológica, os jogos reduzidos de 3X3 jogados com um objectivo provocaram as maiores respostas. Em suma, os jogos reduzidos de 3x3 induziram valores similares nos indicadores técnico-tácticos, mas exigências fisiológicas mais elevadas que os jogos reduzidos de 4X4

Anti-inflammatory and antioxidant nanostructured cellulose membranes loaded with phenolic-based ionic liquids for cutaneous application

The utilization of natural compounds, such as phenolic acids and biopolymers, in the healthcare domain is gaining increasing attention. In this study, bacterial nanocellulose (BC) membranes were loaded with ionic liquids (ILs) based on phenolic acids. These ionic compounds, with improved solubility and bioavailability, were prepared by combining the cholinium cation with anions derived from caffeic, ellagic and gallic acids. The obtained BC-ILs membranes were homogeneous, conformable and their swelling ability agreed with the solubility of each IL. These membranes revealed a controlled ILs dissolution rate in the wet state and high antioxidant activity. In vitro assays performed with Raw 264.7 macrophages and HaCaT keratinocytes revealed that these novel BC-ILs membranes are non-cytotoxic and present relevant anti-inflammatory properties. Diffusion studies with Hanson vertical diffusion cells showed a prolonged release profile of the ILs from the BC membranes. Thus, this work, successfully demonstrates the potential of BC-ILs membranes for skin treatment.publishe

INNUENDO: A cross-sectoral platform for the integration of genomics in the surveillance of food-borne pathogens

Abstract In response to the EFSA call New approaches in identifying and characterizing microbial and chemical hazards, the project INNUENDO (https://sites.google.com/site/theinnuendoproject/) aimed to design an analytical platform and standard procedures for the use of whole-genome sequencing in surveillance and outbreak investigation of food-borne pathogens. The project firstly attempted to identify existing flaws and needs, and then to provide applicable cross-sectorial solutions. The project focused in developing a platform for small countries with limited economical and personnel resources. To achieve these goals, we applied a user-centered design strategy involving the end-users, such as microbiologists in public health and veterinary authorities, in every step of the design, development and implementation phases. As a result, we delivered the INNUENDO Platform V1.0 (https://innuendo.readthedocs.io/en/latest/), a stand-alone, portable, open-source, end-to-end system for the management, analysis, and sharing of bacterial genomic data. The platform uses Nextflow workflow manager to assemble analytical software modules in species-specific protocols that can be run using a user-friendly interface. The reproducibility of the process is ensured by using Docker containers and throught the annotation of the whole process using an ontology. Several modules, available at https://github.com/TheInnuendoProject, have been developed including: genome assembly and species confirmation; fast genome clustering; in silico typing; standardized species-specific phylogenetic frameworks for Campylobacter jejuni, Yersinia enterocolitica, Salmonella enterica and Escherichia coli based on an innovative gene-by-gene methodology; quality control measures from raw reads to allele calling; reporting system; a built-in communication protocols and a strain classification system enabling smooth communication during outbreak investigation. As proof-of-concepts, the proposed solutions have been thoroughly tested in simulated outbreak conditions by several public health and veterinary agencies across Europe. The results have been widely disseminated through several channels (web-sites, scientific publications, organization of workshops). The INNUENDO Platform V1.0 is effectively one of the models for the usage of open-source software in genomic epidemiology.Peer reviewe

Nationwide access to endovascular treatment for acute ischemic stroke in portugal

Publisher Copyright: Copyright Ordem dos M dicos 2021.Introduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular treatment in mainland Portugal and its administrative districts. Material and Methods: A retrospective national multicentric cohort study was conducted, including all ischemic stroke patients treated with endovascular treatment in mainland Portugal over two years (July 2015 to June 2017). All endovascular treatment centers contributed to an anonymized database. Demographic, stroke-related and procedure-related variables were collected. Crude endovascular treatment rates were calculated per 100 000 inhabitants for mainland Portugal, and each district and endovascular treatment standardized ratios (indirect age-sex standardization) were also calculated. Patient time metrics were computed as the median time between stroke onset, first-door, and puncture. Results: A total of 1625 endovascular treatment procedures were registered. The endovascular treatment rate was 8.27/100 000 inhabitants/year. We found regional heterogeneity in endovascular treatment rates (1.58 to 16.53/100 000/year), with higher rates in districts closer to endovascular treatment centers. When analyzed by district, the median time from stroke onset to puncture ranged from 212 to 432 minutes, reflecting regional heterogeneity. Discussion: Overall endovascular treatment rates and procedural times in Portugal are comparable to other international registries. We found geographic heterogeneity, with lower endovascular treatment rates and longer onset-to-puncture time in southern and inner regions. Conclusion: The overall national rate of EVT in the first two years after the organization of EVT-capable centers is one of the highest among European countries, however, significant regional disparities were documented. Moreover, stroke-onset-to-first-door times and in-hospital procedural times in the EVT centers were comparable to those reported in the randomized controlled trials performed in high-volume tertiary hospitalspublishersversionpublishe